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Commentary
Cellscience Reviews Vol 5 No 1
ISSN 1742-8130 |
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Many roads to Rome: multiple genetic events in cancer stem cell formation
Kathleen Kelly
Cell & Cancer Biology Branch, Ctr. for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA.
Received 23rd July © Cellscience 2008
Cancer is the result of multiple genetic changes accumulating in a cell with self-renewal potential. A recent report by Guo et al. [1] identifies increased nuclear β-catenin and c-myc expression as collaborating genetic events that follow PTEN loss in hematopoietic stem cells leading to T cell acute lymphoblastic leukemia (T-ALL). PTEN loss and increased c-myc expression have been hypothesized to synergize in the progression of human T-ALL to a NOTCH1 independent state.
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