Featured Review Cellscience Reviews Vol 3 No 4 ISSN 1742-8130

Targeting proteins of resveratrol in cancer prevention

Resveratrol is a grape-derived polyphenol that has received considerable attention as a preventative agent for cancer and other chronic diseases. The shift in focus from its historical emphasis as a cardioprotective agent in the context of the ‘French paradox’ to chemoprevention in recent years stems from the seminal observation by Pezzuto and coworkers showing that this polyphenol exhibits activities in assays representing major stages of carcinogenesis, respectively, initiation, promotion, and progression. Since then, published data using primarily tissue culture cells, animal studies, and to a more limited extent exploratory investigation in humans, have supported its efficacy against various malignancies. In addition, studies have also begun to address the issue of bioavailability and structure-function relationship, as correlates of its biological effects and therapeutic potential.

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