Novel modulators of the capsaicin receptor

Featured Review
Cellscience Reviews Vol 3 No 4
ISSN 1742-8130

Novel modulators of the capsaicin receptor

Rahul Srinivasan & Joseph C. Glorioso

Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, 15261, USA

The capsaicin receptor (TRPV1) is a member of the transient receptor potential (TRP) superfamily of ion channels. The activation of TRPV1 is upstream of a variety of physiological and pathological processes. The broad role of this ion channel in controlling or activating the functions of many cell types has caused a dramatic increase in research into its regulatory mechanisms. In this review, we summarize current understanding of capsaicin receptor modulation at the levels of transcription, post-translation and activation.

Please click to access complete issue ($8.95) and to download full article in or formats