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Featured Review
Cellscience Reviews Vol 3 No 3
ISSN 1742-8130 |
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RNA Interference-based Cancer Research and Future Therapy
Markus D. Lacher 1 & W. Michael Korn 1,2
1 Division of Gastroenterology, 2 Division of Hematology/Oncology, University of California, San Francisco,
Comprehensive Cancer Center, Box 0128, San Francisco, CA, 94143
Received 18th January © Cellscience 2007
RNAi interference is an RNA silencing process in which double-stranded RNAs (dsRNAs) induce degradation of homologous cellular RNAs. Recently, medical applications for RNAi have emerged. This review will discuss how RNAi technology is being used to specifically 'knockdown' genes aberrantly expressed in cancer. In particular, it will illustrate how RNAi-based approaches have the potential to target most known molecular changes fundamental to cancer. Different methods for delivering therapeutic dsRNAs in vivo will be discussed. Finally, although RNAi-based techniques hold promise for cancer treatment, inherent obstacles in the development path of this approach are outlined.
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