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Commentary
Cellscience Reviews Vol 3 No 3
ISSN 1742-8130 |
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Bioavailable IGF-1: not the culprit in obesity-related cancers?
Patricia A. Thompson1,2, Elizabeth T. Jacobs1,3, Peter Lance4
& María Elena Martínez1,3
1 Arizona Cancer Center,
2 Department of Pathology,
3 Mel and Enid Zuckerman Arizona College
of Public Health,
4 College of Medicine, University of Arizona, Tucson, AZ, USA.
Received 20th January © Cellscience 2007
IGF-1 has been put forward as a biologic mechanism to explain the observed association between obesity and cancer risk. A recent publication by Gram et al., which concluded that ‘bioavailable’ IGF-1 levels are inversely related to ‘central obesity’ challenges the commonly proposed obesity → ‘bioavailable’ IGF-1 → increased cancer risk (Gram et al., 2006). These data are discussed in the context of the complex processes that regulate IGF-1. Emphasis is placed on additional factors that likely impact the obesity-cancer relationship. Specific importance is given to direct biochemical measurement of underlying disturbances in metabolism that occur with obesity to improve our understanding of the obesity-cancer connection and the role of IGF-1.
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