Featured Review Cellscience Reviews Vol 3 No 2 ISSN 1742-8130

BMP3 Signaling in the Formation and Regulation of Bone

Bone Morphogenetic proteins (BMPs) are multi-functional growth factors that have diverse biological activities during embryogenesis and organogenesis. Studies from transgenic and knockout mice as well as from naturally occurring mutations in BMPs and their signaling molecules have shown that BMP signaling plays a fundamental role in bone development and in postnatal bone formation and repair. In this review, we focus on BMP3 and discuss potential roles for BMP3 in the postnatal skeleton. We also propose a model for how BMP3 may regulate bone mass.

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