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Volume 4 Number 2

October 27th 2007

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Table of Contents

Commentaries Page
Host-oriented therapeutics: a new treatment against HIV-1/AIDS? - Hanwen Mao 1
Broadly neutralizing antibodies are produced in some asymptomatic AIDS patients: renewed hope for vaccine development? - Kenneth H. Roux 7
Multivalent integration of local and global signaling through PKA, calcineurin, AKAP79/150, and L-Type calcium channels - Susan S. Taylor, Christopher T. Eggers & Choel Kim 16
Membrane recruitment as a cancer mechanism: a case study of Akt PH domain - Joseph J. Falke 25
Synthetic GEFs for Rho GTPases: a strategy to unwind and assemble the signaling network to control cellular morphology - Tohru Kozasa 31
When Cdk1 is abandoned - Zdenka Ellederova & Charles H. Spruck 35
LKB1: a critical mediator in suppressing initiation, differentiation and metastasis in lung cancer - Chongjuan Wei & Marsha L. Frazier 40
Diet restriction and fruits of the tree of life - Yossi Dagon, Yosefa Avraham & Elliot M. Berry 48

Featured Reviews
Recent developments on slow wave sleep and memory consolidation: more than modest ripples - Kristin L. Eckel-Mahan & Daniel R. Storm 58
Anesthesia, Amyloid and Alzheimer’s - Roderic G. Eckenhoff & Maryellen Fazen Eckenhoff 78
The cellular mechanisms of learning and memory: pattern separation and pattern completion in the hippocampal formation - Brian E. Derrick 97
Epigenetic gene regulation: interdependence of DNA methylation and histone modifications - Concetta G.A. Marfella & Laurie Jackson-Grusby 131
Global DNA methylation in the modeling of tumoral progression - Yu-Wei Leu & Tim H.-M. Huang 148
Examining the role for lineage-determinant transcription factors in cellular differentiation - Amy S. Weinmann 171
Gene-specific control of inflammation by TLR-induced chromatin modifications - Michael Surace & Liwu Li 192
Proficiency of DNA repair networks in stem cells as determinants of aging - Vaidehi Krishnan, Baohua Liu, & Zhongjun Zhou 203
Regulation of hepatic metabolism by PGC-1 transcriptional coactivators - Jennifer L. Estall & Zoltan Arany 225

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