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Volume 3 Number 2 October 27th 2006

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Table of Contents

Commentaries Page
Investigating HIV-1 latent infection: challenges and recent progress - Andrew P. Rice 1
Role of HERVs in Primate Genome Evolution - Heui-Soo Kim 7
Insights into dsRNA-dependent signaling pathways mediated by Toll-like receptor 3 - Monica Ruse & Ulla G. Knaus 15
Carcinogenic Inflammation: Novel Tumor-enhancing Cytokines - Elizabeth A. Grimm & Nancy J. Poindexter 20
Primate testing of siRNAs reveals unexpected duration and efficacy - John J. Rossi 25
Mast Cells Dampen Immune Reactions against Transplants - An Ever Growing List of Their Functions - Toshiaki Kawakami, Michael J. Poderycki & Yuko Kawakami 30
GIT2: master regulator of the CZH family of Rho-GEFs, or simply regulating the subcellular location, and GTPase activity of ARF6? - J. Adrian Lunn 36
Leptin, Insulin, AND PTEN: Divergent effects on hypothalamic neurons explained? - Jennifer W. Hill 43
Tobacco Addiction: Looking Beyond the Behavioral Pharmacology of Nicotine - Rebecca C. Steiner 52

Featured Reviews
BMP3 Signaling in the Formation and Regulation of Bone - Laura W. Gamer & Vicki Rosen 58
BMP Signaling and the Regulation of Endochondral Bone Formation - Kelsey N. Retting & Karen M. Lyons 67
PTEN: Beyond its role as a tumor suppressor - Minna Woo 89
Mitochondrial Dysfunction in Skeletal Muscle and Adipose Tissue: A Cause of Skeletal Muscle Insulin Resistance? - David C. Wright 104
The Hippocampus and Memory: the Importance of Space and Timing - Norihiro Yoshida, Kazunobu Togashi, Kyonsoo Hong & Makoto Nishiyama 115
Neurotransmitter Release at a Tonic Synapse: how ordinary mechanisms accomplish an extraordinary task - Ruth Heidelberger & Barbara Innocenti 151
Selective presynaptic actions of volatile anesthetics: unraveling the synaptic mechanisms of anesthesia - Hugh C. Hemmings Jr. 184
Forebrain-Cerebellar Interactions During Learning - Craig Weiss, Aldis P. Weible, Roberto Galvez, John F. Disterhoft 200

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