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Featured Review
Cell Science Reviews Vol 6 No 3
ISSN 1742-8130 |
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The therapeutic potential of targeting microRNAs in cancer
Breege V. Howley & Howard O. Fearnhead
Pharmacology & Therapeutics, School of Medicine & National Centre for Biomedical Engineering Science, National University of Ireland-Galway, University Road, Galway, Ireland.
Received 16th January © Cell Science 2010
MicroRNAs are small non-coding RNAs that repress translation of mRNA and post-transcriptionally regulate mRNA levels. Deregulation of microRNA expression is a hallmark of cancer and many microRNAs have been labelled 'oncomirs' for their contribution to tumorigenesis. The feasibility of introducing microRNA mimics or inhibitors into cancer cells has been demonstrated while several in vivo mouse models of cancer support the idea that microRNA-based therapeutics will be efficacious. In this review, we will briefly outline microRNA function and the role of microRNAs in tumorigenesis and discuss emerging microRNA-based therapy for cancer.
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