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Commentary
Cell Science Reviews Vol 6 No 3
ISSN 1742-8130 |
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Molecular scaffold unfolds mysteries surrounding energy balance
Jason K. Kim
Program in Molecular Medicine, Division of Endocrinology, Metabolism and Diabetes, Department of Medicine, University of Massachusetts Medical School, Worcester, USA.
Received 25th January © Cell Science 2010
Kinase suppressor of Ras 2 (KSR2) is a molecular scaffold that was recently identified to regulate energy balance and metabolism. KSR2 is shown to directly activate AMP-activated protein kinase (AMPK) and increase lipid oxidation and glucose metabolism. KSR2 deficient mice became obese due to reduced energy expenditure and developed insulin resistance in skeletal muscle, adipose tissue and liver. Thus, KSR2 is a novel scaffold protein that regulates AMPK, and a potential target in the treatment of obesity and diabetes.
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