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Commentary
Cell Science Reviews Vol 6 No 3
ISSN 1742-8130 |
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Homeostatic circuitry pushes back
Jackson J. Cone 1 & Mitchell F. Roitman 2
1 University of Illinois at Chicago, Graduate Program in Neuroscience &
2 University of Illinois at Chicago, Department of Psychology, Chicago, Illinois, USA.
Received 15th January © Cell Science 2010
Mesolimbic circuitry can override homeostatic signals and promote food intake in the absence of caloric need which contributes to the onset of obesity. A recent set of studies described by Leinninger and colleagues suggest that homeostatic circuitry maybe able to re-establish normal mesolimbic signaling. They identify a distinct population of leptin receptor expressing neurons in the lateral hypothalamic area that, when exposed to leptin, restore dopamine content and reduce feeding in obese mice. The findings bring to light a potential selective target for the treatment of obesity.
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