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Commentary
Cell Science Reviews Vol 6 No 2
ISSN 1742-8130 |
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Less TORC is more: Therapeutic extension of mammalian lifespan
ChiKwan Tsang & X.F. Steven Zheng
Department of Pharmacology & Cancer Institute of New Jersey (CINJ), Robert Wood Johnson Medical School, Piscataway NJ, USA
Received 23rd September © Cell Science 2009
A recent paper reveals that inhibition of mammalian target of rapamycin (mTOR) by the anti-cancer drug rapamycin significantly extends longevity in both male and female mice, and the effect of rapamycin appears to be age-independent. This key finding, taken together with previous studies in yeast, worms and flies, indicates that TOR is a truly evolutionarily conserved protein which regulates longevity. This study provides one of the first examples of the therapeutic extension of lifespan in mammals.
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