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Featured Review
Cell Science Reviews Vol 6 No 1
ISSN 1742-8130 |
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Epigenetics in embryonic and adult neurogenesis
Xiaoming Zhan & Jiang Wu
Dept. of Physiology & Developmental Biology, University of Texas Southwestern Medical Center, Dallas, USA.
Received 15th July © Cell Science 2009
The decisions of neural stem cells to self-renew or to differentiate and adopt specific neural cell fates are under precise temporal and spatial controls. Mammalian neurogenesis requires the cooperative functions of extracellular signals, transcription factors and epigenetic regulators. Epigenetic regulators remodel chromatin structures to either facilitate or repress gene expression. Their functions are context-dependent during both embryonic and adult neurogenesis. This review discusses the recent findings and mechanistic studies of epigenetic factors regulating both the programmed and activity-dependent neurogenesis in mammalian embryonic and adult brains.
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