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Commentary
Cell Science Reviews Vol 5 No 4
ISSN 1742-8130 |
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SV turnover in nerve terminals - two vesicles for the price of one?
Mike Cousin
Centre for Integrative Physiology, Hugh Robson Building, George Square, University of Edinburgh, Scotland, UK
Received 2nd April © Cell Science 2009
The efficient retrieval of synaptic vesicles (SVs) after their fusion is critical for central nerve terminal function and maintenance of the fidelity of neurotransmission. A number of different retrieval routes occur in nerve terminals, however little is known about the endocytosis mechanisms that respond to the fusion of a single SV. A recent paper in Neuron has addressed this issue using a novel genetic reporter. The results are surprising, suggesting that two SVs are retrieved for every SV that fuses with the plasma membrane. These unexpected results have implications for current models of SV recycling and may stimulate a revaluation of the molecular pathways involved.
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